Skip to main content. Skip to left menu.

AVAPRO: The power of proven renal protection

AVAPRO is indicated for the treatment of diabetic nephropathy with an elevated serum creatinine and proteinuria (>300 mg/day) in patients with type 2 diabetes and hypertension. In this population, AVAPRO reduces the rate of progression of nephropathy as measured by the occurrence of doubling of serum creatinine or end-state renal disease (need for dialysis or
renal transplantation).11
AVAPRO significantly decreased the rate of progression of nephropathy in patients with hypertension and type 2 diabetes 11

AVAPRO demonstrated early (3 months) and sustained (2.6 years) renal protection11
AVAPRO demonstraded early and sustained renal protection

Multicenter, randomized, double-blind, placebo-controlled study.

Primary composite end point: time to occurrence of doubling of baseline serum creatinine, end-stage renal disease [ESRD] (serum creatinine >6 mg/dL, dialysis, or
renal transplantation), or all-cause death. Patients reaching primary end point: 32.6% (189/579) in the AVAPRO group; 41.1% (233/567) in the amlodipine group; and 39.0% (222/569) in the control group.

Adjunctive antihypertensive therapy (excluding ACE inhibitors, ARBs, and CCBs) used as necessary to achieve target BP in all 3 groups: systolic <135 mm Hg; diastolic <85 mm Hg.

Nephropathy is defined as elevated serum creatinine and proteinuria (>300 mg/day).
Control defined as placebo plus permitted adjunctive antihypertensive therapy.

In patients with proteinuria, monitor serum potassium.


Download additional study information following the full Prescribing Information
AVAPRO significantly lowered proteinuria25
AVAPRO significantly lowered proteinuria

Adverse drug experiences included dizziness, orthostatic dizziness, and orthostatic hypotension.

§Last observation carried forward; mean duration of follow up was 2.6 years.
Control defined as placebo plus permitted adjunctive antihypertensive therapy.

In IDNT, nephropathy was defined as proteinuria >900 mg/day and elevated serum creatinine.


WARNING: USE IN PREGNANCY
When pregnancy is detected, discontinue AVAPRO or AVALIDE as soon as possible. When used in pregnancy during the second and third trimesters, drugs that act directly on the renin-angiotensin system can cause injury and even death to the developing fetus. [See Warnings and Precautions: Fetal/Neonatal Morbidity and Mortality in the full Prescribing Information.]